Expanding the biological limits of degeneration of temporomandibular structures. Literature review
Abstract
The temporomandibular joint (TMJ) is an essential structure that allows the jaw to open and close, and its degeneration can cause pain and dysfunction. This literature review begins by highlighting the importance of understanding all the underlying biological mechanisms of TMJ degeneration to develop better treatment approaches. This review aims to gather all the information on the molecular mechanisms, hormonal and genetic factors involved in signaling pathways and interactions that are potentially related to jaw disorders. The literature was selected by searching electronic databases. It was determined that in the face of an inflammatory and degenerative process of the TMJ, the presence of several proteins, molecules, hormones, and increased gene expression is present in large volume, however, future research with larger samples is needed to improve understanding in diagnostic and therapeutic approaches in this field.
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