Factors associated with the prevention of Alzheimer's in adults from Morona city

  • Diana Ibeth Coral Bastidas Universidad Católica de Cuenca | Cuenca | Ecuador
  • Rodolfo Moisés Espinosa Tigre Universidad Católica de Cuenca | Cuenca | Ecuador
  • Carmen Elizabeth Cevallos Vallejo Universidad Católica de Cuenca | Cuenca | Ecuador
  • Scarlett Sayled Prado Granda Universidad Católica de Cuenca | Cuenca | Ecuador
Keywords: Alzheimer; genetic condition; cardiovascular health; nutrition habits; chronic stress

Abstract

The research focuses on the factors associated with the prevention of Alzheimer's disease in adults from the Morona canton, Morona Santiago province, Ecuador. This neurodegenerative disease accounts for 60% to 70% of dementia diagnoses worldwide, highlighting the need to identify elements related to its prevention. The objective is to demonstrate how factors such as genetic predisposition, cardiovascular health, nutritional habits, physical activity, chronic stress, cognitive stimulation, mental health, and the presence of social support networks positively contribute to preventing Alzheimer's disease. The research follows a non-experimental design, applying correlation models and multiple linear regression analysis. Data collection was conducted through document review and surveys administered to a sample of 221 adults. The data were analyzed using Spearman's correlation and multiple linear regression analysis. The results, including an R² value of 0.830, indicate that the model has a high probability of accurately describing the phenomenon, while the Spearman correlation coefficient of 0.826 demonstrates a strong correlation between the associated factors and Alzheimer's disease. The study concludes that these associated factors directly influence the prevention of Alzheimer's disease.

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...

Author Biographies

Diana Ibeth Coral Bastidas, Universidad Católica de Cuenca | Cuenca | Ecuador

Licenciada en Enfermería con una maestría en Gestión de la Seguridad Clínica del paciente y Calidad de la Atención Sanitaria. Actualmente soy Docente de la Universidad Católica de Cuenca

Rodolfo Moisés Espinosa Tigre, Universidad Católica de Cuenca | Cuenca | Ecuador

Doctorado en Filosofía con especialidad en Administración. Poseo títulos de Magíster en Docencia Universitaria y Administración Educativa, Magíster en Administración de Empresas con mención en Dirección y Gestión de Proyectos, y Magíster en Interconectividad de Redes. Me desempeño como docente de la carrera de Enfermería, a cargo del área de investigación, en la Universidad Católica de Cuenca, campus Morona.

Carmen Elizabeth Cevallos Vallejo, Universidad Católica de Cuenca | Cuenca | Ecuador

Licenciada en Enfermería, con una maestría en Gestión de la Seguridad Clínica del paciente y Calidad de la Atención Sanitaria. Actualmente soy Docente de la Universidad Católica de Cuenca

Scarlett Sayled Prado Granda, Universidad Católica de Cuenca | Cuenca | Ecuador

Estudiante de quinto ciclo de la carrera de Enfermería en la Universidad Católica de Cuenca campus Macas. Actualmente estoy colaborando  con esta investigación relacionada con el área de salud.

References

Balouch, S., Rifaat, E., Chen, H., & Tabet, N. (2019). Social networks and loneliness in people with Alzheimer’s dementia. International Journal of Geriatric Psychiatry, 34, 666 - 673. https://doi.org/10.1002/gps.5065.

Berger, T., Lee, H., Young, A., Aarsland, D., & Thuret, S. (2020). Adult hippocampal neurogenesis in major depressive disorder and Alzheimer’s disease. Trends in molecular medicine, 26(9). https://doi.org/10.1016/j.molmed.2020.03.010.

Broce, I., Tan, C., Fan, C., Jansen, I., Savage, J., Witoelar, A., Wen, N., Hess, C., Dillon, W., Glastonbury, C., Glymour, M., Yokoyama, J., Elahi, F., Rabinovici, G., Miller, B., Mormino, E., Sperling, R., Bennett, D., McEvoy, L., Brewer, J., Feldman, H., Hyman, B., Pericak-Vance, M., Haines, J., Farrer, L., Mayeux, R., Schellenberg, G., Yaffe, K., Sugrue, L., Dale, A., Posthuma, D., Andreassen, O., Karch, C., & Desikan, R. (2018). Dissecting the genetic relationship between cardiovascular risk factors and Alzheimer’s disease. Acta Neuropathologica, 137, 209-226. https://doi.org/10.1007/s00401-018-1928-6.

Carbone, E., Gardini, S., Pastore, M., Piras, F., Vincenzi, M., & Borella, E. (2021). Cognitive Stimulation Therapy (CST) for older adults with mild-to-moderate dementia in Italy: effects on cognitive functioning and on emotional and neuropsychiatric symptoms. The journals of gerontology, 76(9), 1700–1710. https://doi.org/10.1093/geronb/gbab007

Castro-Jiménez, L. E., & Galvis-Fajardo, C. A. (2018). Efecto de la actividad física sobre el deterioro cognitivo y la demencia. Revista Cubana de Salud Pública, 44(3). http://scielo.sld.cuhttp://scielo.sld.cu.

Díaz-Santos, M., Yañez, J., & Suárez, P. (2022). Alzheimer’s disease in bilingual latinos: clinical decisions for diagnosis and treatment planning. Alzheimer’s & dementia: the journal of the Alzheimer’s Association, 18(59). https://doi.org/10.1002/alz.064253.

Dong, H., & Csernansky, J. (2019). Editorial: Stress and its impact on Alzheimer’s disease. Neurobiology of stress, 10. https://doi.org/10.1016/j.ynstr.2019.100167.

Fernández-Fleites, Z., Broche-Pérez, Y., & Jiménez-Puig, E. (2022). Conocimiento sobre factores protectores y de riesgo en las demencias. Revista Cubana de Medicina General Integral, 38(4). http://orcid.org/0000-0002-3450-7374.

Franks, K., Bransby, L., Saling, M., & Pase, M. (2021). Association of stress with risk of dementia and mild cognitive impairment: A systematic review and meta-analysis. Journal of Alzheimer’s Disease, 82(4), 1573-1590. https://doi.org/10.3233/JAD-210094.

Govindugari, V. L., Golla, S., Reddy, S. D. M., Chunduri, A., Nunna, L. S. V., Madasu, J., Shamshabad, V., Bandela, M., & Suryadevara, V. (2023). Thwarting Alzheimer’s disease through healthy lifestyle habits: hope for the future. Neurology international, 15(1), 162–187. https://doi.org/10.3390/neurolint15010013.

Guo, Y., & Shi, J. (2024). Factors Associated With Psychological Wellbeing in Home Care Older Adults With Alzheimer’s Disease: A Longitudinal Analysis. Journal of Applied Gerontology, 43(8), 1069-1081. https://doi.org/10.1177/07334648241231406

Harith, M. (2023). The interplay of tau and amyloid beta pathologies in Alzheimer’s disease. Journal of Student Research, 12(4). https://doi.org/10.47611/jsrhs.v12i4.5732.

Jin, W., Bu, X., Wang, Y., Li, L., Li, W., Liu, Y., Zhu, C., Yao, X., Chen, Y., Gao, C., Zhang, T., Zhou, H., Zeng, F., & Wang, Y. (2017). Reduced cardiovascular functions in patients with Alzheimer’s disease. Journal of Alzheimer’s disease: JAD, 58(3), 919-925. https://doi.org/10.3233/JAD-170088.

Khusaifan, S., & Keshky, M. (2016). Social support as a mediator variable of the relationship between depression and life satisfaction in a sample of Saudi caregivers of patients with Alzheimer’s disease. International Psychogeriatrics, 29, 239 - 248. https://doi.org/10.1017/S1041610216001824.

Jaberi, S., & Fahnestock, M. (2023). Mechanisms of the beneficial effects of exercise on brain-derived neurotrophic factor expression in Alzheimer’s disease. Biomolecules, 13(11), 1577. https://doi.org/10.3390/biom13111577.

Jiménez-Palomares, M., González-López-Arza, M., Garrido-Ardila, E., Montanero-Fernández, J., Rodríguez-Domínguez, T., & Rodríguez-Mansilla, J. (2022). Effects of a cognitive stimulation program in institutionalized patients with dementia. Journal of Personalized Medicine, 12. https://doi.org/10.3390/jpm12111808.

Justo-Henriques, S., Pérez-Sáez, E., Carvalho, J., Lemos, R., & Ribeiro, Ó. (2024). Effects of an individual cognitive stimulation intervention on global cognition, memory, and executive function in older adults with mild to moderate Alzheimer’s disease. The Clinical neuropsychologist, 1-19. https://doi.org/10.1080/13854046.2024.2416568.

Lorenzo-Mora, A. M., Lozano-Estevan, M. D. C., Ghazi, Y., & González-Rodríguez, L. G. (2023). Enfermedad de Alzheimer. Evidencia actual sobre el papel preventivo de la nutrición. Nutrición hospitalaria, 40(2), 41–45. https://doi.org/10.20960/nh.04954.

Luo, J., Rasmussen, I., Nordestgaard, B., Tybjaerg-Hansen, A., Thomassen, J., & Frikke-Schmidt, R. (2024). Abstract MP23: Cardiovascular Diseases and Risk of Dementia in the General Population: Observational and Genetic Studies. Circulation, 149. https://doi.org/10.1161/circ.149.suppl_1.mp23.

Lyons, C., & Bartolomucci, A. (2020). Stress and Alzheimer’s disease: ¿A senescence link? Neuroscience & Biobehavioral Reviews, 115, 285-298. https://doi.org/10.1016/j.neubiorev.2020.05.010.

Milligan Armstrong, A., Porter, T., Quek, H., White, A., Haynes, J., Jackaman, C., Villemagne, V., Munyard, K., Laws, S. M., Verdile, G., & Groth, D. (2021). Chronic stress and Alzheimer’s disease: the interplay between the hypothalamic-pituitary-adrenal axis, genetics and microglia. Biological reviews of the Cambridge Philosophical Society, 96(5), 2209–2228. https://doi.org/10.1111/brv.12750.

McCarthy, E. P., Chang, C. H., Tilton, N., Kabeto, M. U., Langa, K. M., & Bynum, J. P. W. (2022). Validation of claims algorithms to identify Alzheimer’s disease and related dementias. The journals of gerontology, 77(6), 1261–1271. https://doi.org/10.1093/gerona/glab373.

Nicolas, G. (2024). Recent advances in Alzheimer disease genetics. Current Opinion in Neurology, 37, 154 - 165. https://doi.org/10.1097/WCO.0000000000001242.

Organización Mundial de la Salud OMS. (2021). Informe sobre la situación mundial de la respuesta de la Salud Pública a la demencia. Resumen Ejecutivo. World Health Organization.

Oveisgharan, S., Yu, L., de Paiva Lopes, K., Tasaki, S., Wang, Y., Menon, V., Schneider, J. A., Seyfried, N. T., & Bennett, D. A. (2024). Proteins linking APOE 4 with Alzheimer’s disease. Alzheimer’s & dementia: the journal of the Alzheimer’s Association, 20(7), 4499–4511. https://doi.org/10.1002/alz.13867.

Piirainen, S., Youssef, A., Song, C., Kalueff, A., Landreth, G., Malm, T., & Tian, L. (2017). Psychosocial stress on neuroinflammation and cognitive dysfunctions in Alzheimer’s disease: the emerging role for microglia? Neuroscience & Biobehavioral Reviews, 77, 148-164. https://doi.org/10.1016/j.neubiorev.2017.01.046.

Saeed, A., Lopez, O., Cohen, A., & Reis, S. (2023). Cardiovascular disease and Alzheimer’s disease: The heart–brain axis. Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 12. https://doi.org/10.1161/JAHA.123.030780.

Schelke, M. W., Hackett, K., Chen, J. L., Shih, C., Shum, J., Montgomery, M. E., Chiang, G. C., Berkowitz, C., Seifan, A., Krikorian, R., & Isaacson, R. S. (2016). Nutritional interventions for Alzheimer’s prevention: a clinical precision medicine approach. Annals of the New York Academy of Sciences, 1367(1), 50–56. https://doi.org/10.1111/nyas.13070.

Seemiller, L. R., Flores-Cuadra, J., Griffith, K. R., Smith, G. C., & Crowley, N. A. (2024). Alcohol and stress exposure across the lifespan are key risk factors for Alzheimer’s Disease and cognitive decline. Neurobiology of stress, 29. https://doi.org/10.1016/j.ynstr.2024.100605.

Terrado Quevedo, S., Serrano Durán, C., Galano Guzmán, Z., Betancourt Pulsán, A., & Jiménez de Castro Morgado, M. (2017). Enfermedad de Alzheimer, algunos factores de riesgo modificables. Revista Información Científica, 96(5), 967-977.

Verheijen, J., & Sleegers, K. (2018). Understanding Alzheimer disease at the interface between genetics and transcriptomics. Trends in genetics: TIG, 34(6), 434-447. https://doi.org/10.1016/j.tig.2018.02.007.

Von Cederwald, B., Josefsson, M., Wahlin, A., Nyberg, L., & Karalija, N. (2022). Association of cardiovascular risk trajectory with cognitive decline and incident dementia. Neurology, 98, 2013 - 2022. https://doi.org/10.1212/WNL.0000000000200255.

Published
2025-02-24
How to Cite
Coral Bastidas, D. I., Espinosa Tigre, R. M., Cevallos Vallejo, C. E., & Prado Granda, S. S. (2025). Factors associated with the prevention of Alzheimer’s in adults from Morona city. Religación, 10(44), e2501370. https://doi.org/10.46652/rgn.v10i44.1370
Section
Health Sciences